Showing posts with label AMD. Show all posts
Showing posts with label AMD. Show all posts

Thursday, June 16, 2011

A glass of CABERNET or MERLOT for a leaky case of AMD

Extract of my guest post at maiBlog, a radiology-focused blog.

"Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness in adults over 50 years age. While 90% of AMD patients have the dry-type AMD (atrophic), it is the wet AMD (exudative), driven by choroidal neovascularization (CNV), which is responsible for severe and acute vision loss in over 90% of the patients. Famous people, like the artist Georgia O’Keefe, entertainer Bob Hope and the author Henry Grunwald have coped with AMD. There are over 1.6 million people with AMD in the United States and about 200,000 people are diagnosed with wet AMD every year


One promising approach in late-stage clinical development is the use of beta-radiation to selectively target the proliferating cells in the macular lesion. A small company 40-miles south of San Francisco called NeoVista in Newark, Calif., is at the forefront of testing an epimacular brachytherapy device in the pivotal CABERNET (CNV Secondary AMD Treated with BEta RadiatioN Epiretinal Therapy) Study. ..."

Click here to read full post at maiBlog.

(Find this post at InternetArchive here.)


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Monday, November 22, 2010

Mining aminoacyl tRNA synthases (aaRSs) for anti-angiogenic factors

Aminoacyl tRNA synthases (aaRSs) are ancient catalytic enzymes that catalyze the first step in protein synthesis, transfer of amino acid to its cognate tRNA, something that we learned years ago in Stryer’s Biochemistry.  But, these enzymes are also moonlighting proteins, with alternate splice forms or natural proteolytic fragments, acting as cytokines, angiogenic factors or angiostatic factors. The one that caught my eye was tryptophanyl-tRNA synthase (TrpRS) fragment which is antiangiogenic and is in clinical development for retinal diseases [...][...].
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