Tuesday, April 3, 2012

Postcard From the AACR 2012 Annual Meeting - Part 2



AACR 2012 meeting summary - Part 2

Part 1 (previous post): 
  • Various cancers (lung, prostate, breast, ovarian, cervical liver, stomach, pancreatic, melanoma, skin, head and neck, urothelial, brain cancers and gliomas, lymphomas and leukemias.)
  • Drugs and strategies targeting cell metabolism, epigenetics, angiogenesis and microenvironment, p53, PI3K.
  • Tackling resistance and managing Stage IV disease
  • Cancer models
Part 2 (this post):
  • Funding situation, 
  • Clinical trials' issues, patients' concerns
  • Epidemiology, prevention
Part 3 (next post):
  • Mechanisms of cancer
  • NGS; TCGA project
Part 4 (following post):
  • The quotes
  • The grapevine
  • and what else!

FUNDING SITUATION


  • $$ needed. MT @AACR: #AACR Board pronounces crisis in cancer research funding its top priority http://ow.ly/a0LI4 #discoverymatters. -- Michael Fisch‏ @fischmd 4:23 PM - 1 Apr 12 via HootSuite • Tweet 
  • Flat means, less money 4 research due 2 inflation. RT @OnlineBiotech #AACR flat NIH Funding is Crisis 4 Cancer Research http://bit.ly/HzIFBq. -- Naoto T. Ueno 上野直人‏ @teamoncology 2:52 PM - 1 Apr 12 via YoruFukurou • Tweet 
Patient advocacy groups stepping up to fill the gap!
  • 【#AACR 101】 Stand up to cancer focus on supporting translational research by team effort (dream team). -- Naoto T. Ueno 上野直人‏ @teamoncology 1:24 PM - 1 Apr 12 via Facebook • Tweet 
  • 【#AACR 101】SU2C aims to raise significant funds through online and televised efforts. Very different from Susan G Komen. -- Naoto T. Ueno 上野直人‏ @teamoncology 1:24 PM - 1 Apr 12 via Facebook • Tweet 
  • Stand Up To Cancer..."not science for science, science for patients". Excellent intro to the dream teams. #aacr. -- Caroline Rousseau‏ @CaroRousse 1:33 PM - 1 Apr 12 via Twitter for Android • Tweet
  • Attending remarkable session of #SU2C tribute to#LauraZiskin co-founder of Stand Up to Cancer who lost her battle in 2011. #AACR. -- PKI Life Science‏ @PKILifeScience :32 PM - 1 Apr 12 via Mobile Web • Tweet
  • 【#AACR 101】 What is Stand Up to Cancer? A charitable program of the Entertainment Industry Foundation (EIF) by... http://fb.me/1cOev29ZO. -- Naoto T. Ueno 上野直人‏ @teamoncology 1:23 PM - 1 Apr 12 via Facebook • Tweet 
  • #SU2C Dream Team 4 Transl Res w/@CancerResearch Inst expected 2 be announc in fall (Marge Foti said @ #AACR). -- Serena Stockwell‏ @OncologyTimes 12:40 PM - 1 Apr 12 via Twitter for iPad • Tweet


CLINICAL TRIAL ISSUES, PATIENTS' CONCERNS, ETC. 


Tobacco use is a confounding factor in clinical  trials and drug efficacy
  • Benjamin Toll of Yale talking on assessing tobacco use in clinical trials & research #AACR. -- Serena Stockwell‏ @OncologyTimes 2:07 PM - 1 Apr 12 via Twitter for iPad •  Tweet
  • Even among well-designed NCI cooperative group trials only a minority assess tobacco use- Benjamin Toll #AACR. -- Serena Stockwell‏ @OncologyTimes 2:21 PM - 1 Apr 12 via Twitter for iPad • Tweet
  • Toll, #AACR, Growing evidence that assessing tobacco use is imp in trials 4 many cancers, not just lung, etc. -- Serena Stockwell‏ @OncologyTimes 2:20 PM - 1 Apr 12 via Twitter for iPad • Tweet
  • Benjamin Toll #AACR quotes E Gritz in rec tobacco status be collected @ ca diag, treatment intake, & thru followup. -- Serena Stockwell‏ @OncologyTimes 2:12 PM - 1 Apr 12 via Twitter for iPad • Tweet
  • Graham Warren #AACR: I think tobacco use is affecting the efficacy of cancer treatments. -- Serena Stockwell‏ @OncologyTimes 1:44 PM - 1 Apr 12 via Twitter for iPad • Tweet
  • Graham Warren talking on effect of tobacco on tumor biology and cancer treatment outcomes#AACR. -- Serena Stockwell‏ @OncologyTimes 1:30 PM - 1 Apr 12 via Twitter for iPad • Tweet
Need to increase minority participation
  • #AACR: EMPaCT is a national program focused on evidence-based solutions to improving minority participation in clinical trials. -- J Nat'l Cancer Inst‏ @JNCI_Now 8:23 AM - 2 Apr 12 via web • Tweet
  • #AACR: EMPaCT aims to provide menu of recruitment models of minority participation in clinical trials tailored to national cancer centers. -- J Nat'l Cancer Inst‏ @JNCI_Now 8:24 AM - 2 Apr 12 via web • Tweet
  • SP: Mentions that we still need to improve our analysis of racial/ethnic groups; specifically not great maps for hispanic populations #AACR. -- Kenna Shaw‏ @wyattsgirl 2:08 PM - 2 Apr 12 via TweetDeck • Tweet
Patients concerns, involvement, HIPPA impact

  • TC: new study re: public perceptions of tissue and banking- public has mixed opinions on broad vs. specific consent #AACR. -- Kenna Shaw‏ @wyattsgirl 2:41 PM - 2 Apr 12 via TweetDeck • Tweet
  • TC: asked public: who owns your sample? 25% say ME, 25% Researcher, 44% research institution, rest- other #AACR. -- Kenna Shaw‏ @wyattsgirl 2:41 PM - 2 Apr 12 via TweetDeck • Tweet

  • TC: RoR/Incidentalome: Public answers we want our results to me and my doctor! #AACR. -- Kenna Shaw‏ @wyattsgirl 2:42 PM - 2 Apr 12 via TweetDeck • Tweet


I-SPY2 update
  • Berry: I-SPY 2 has "offspring" trials using same design in melanoma, colorectal cancer, Alzheimer's, HIV, acute heart failure and H1N1#AACR. -- John Speakman‏ @speakman 12:05 PM - 1 Apr 12 via SocialScope • Tweet
  • Don Berry: I-SPY 2 adaptive trial now has 200 patients randomized, four agents being used#AACR #cabig #clinicaltrials. -- John Speakman‏ @speakman 11:54 AM - 1 Apr 12 via SocialScope • Tweet 
  • @speakman Not happy about randomizing inflammatory breast cancer patients in ISY-2. Hard for me to justify standard of care in HER2- IBC. -- Naoto T. Ueno 上野直人 ‏ @teamoncology • Tweet

  • Y. Shyr: Adaptive trial design will not let you diminish the sample size. It will let you decide earlier. #AACR. -- Philippe Aftimos MD‏ @aftimosp 12:39 PM - 2 Apr 12 via Twitter for iPad • Tweet
  • "it's time to conduct adaptive trials" Y. Shyr#AACR. -- Philippe Aftimos MD‏ @aftimosp 12:41 PM - 2 Apr 12 via Twitter for iPad • Tweet
Misc.
  • L. Siu: profile all patients even though they might be enrolled in non-nested clinical trials #AACR. -- Philippe Aftimos MD‏ @aftimosp 12:09 PM - 2 Apr 12 via Twitter for iPad • Tweet
  • Had to smile today... Neal Rosen outlined how to design adaptive TKI trials & I've only been saying same thing on blog for ages #aacr. -- Sally Church‏ @MaverickNY 12:45 PM - 2 Apr 12 via Echofon • Tweet

EPIDEMIOLOGY, HEALTH DISPARITIES, TOBACCO USE and PREVENTION


Prevention

  • Effective prevention and early detection has capacity to reduce cancer deaths by more than 75% in the future. #AACR. -- J Nat'l Cancer Inst‏ @JNCI_Now 9:25 AM - 2 Apr 12 via web • Tweet
  • More than 1/2 of cancer preventable. Exercise, eat well, reduce stress. #AACR http://fb.me/Vbd9OPpQ. -- Naoto T. Ueno 上野直人‏ @teamoncology 1:33 PM - 1 Apr 12 via Facebook • Tweet

  • Vogelstein: A feasible goal is 75% reduction in cancer deaths in the next few decades #AACR. -- Cancer Minute‏ @CancerMinuteGW 2:31 PM - 2 Apr 12 via web • Tweet
  • Prevention implementation article mentioned by Dr Vogelstein is here #aacr http://m.stm.sciencemag.org/content/4/127/127rv4. -- Dr. Kate Wolin‏ @wolinlab 2:16 PM - 2 Apr 12 via HootSuite • Tweet
  • Vogelstein: prevention is another way to conquer cancer #AACR. -- Cancer Minute‏ @CancerMinuteGW 2:15 PM - 2 Apr 12 via web • Tweet
    • What a surprising comment? :) RT@CancerMinuteGW Vogelstein: prevention is another way to conquer cancer #AACR. -- Naoto T. Ueno 上野直人‏ @teamoncology 2:30 PM - 2 Apr 12 via Twitterrific for Mac 
    • @teamoncology Indeed =) I think he wanted to emphasize the point that it can't be all about therapeutics. • Tweet

  • Metformin for cancer prevention- diabetes pts. who use Metformin have reduced cancer risk.#AACR. -- David Woessner‏ @pinfoto 12:15 PM - 2 Apr 12 via Echofon • Tweet
Tobacco, smoking, obesity
  • Tobacco use accounts for 33% of cancer in U.S.#AACR. -- J Nat'l Cancer Inst‏ @JNCI_Now 10:11 AM - 2 Apr 12 via web • Tweet
  • #AACR: Tobacco the leading cause of health disparities. -- J Nat'l Cancer Inst‏ @JNCI_Now 8:22 AM - 2 Apr 12 via web • Tweet
  • RT @OncologyTimes: Graham Warren shows slide w/ TINY type almost filling screen listing the 600 additives in tobacco smoke! #AACR. -- Stefanie Greene‏ @StefanieAACR Tweet 
  • So true. Half the battle (against #cancer) is not cloning genes, it's changing habits (smoking, obesity, diet, exercise) @bstockwell #aacr. -- Naoto T. Ueno 上野直人‏ @teamoncology 11:57 AM - 1 Apr 12 via TweetList Pro • Tweet
  • Strong Oral Carcinogen Identified in Smokeless Tobacco http://ow.ly/a1Q9E - News from #AACR. -- Stefanie Greene‏ @StefanieAACR 11:10 AM - 2 Apr 12 via HootSuite • Tweet
  • RT @smerv: #AACR Strong Oral Carcinogen Identified in Smokeless Tobacco:http://bit.ly/HGV2M3 via @AACR. -- Dirk Hanson‏ @Dirk57 2:27 PM - 2 Apr 12 via TweetDeck • Tweet
  • J. Mathers from UK at #AACR talking abt how some foods & obesity lead to inflammation, which silences defense genes, leads to tumors. -- AICR‏ @aicrtweets 11:53 AM - 1 Apr 12 via web • Tweet
Cellphone radiation and cancer risk (is it still controversial)
  • Exposure to ionizing radiation, such as from radiation therapy, is known to increase the risk of cancer. #AACR. -- J Nat'l Cancer Inst‏ @JNCI_Now 3:20 PM - 2 Apr 12 via Twitter for iPhone • Tweet
  • Children have greater risk than adults for developing brain cancer from cell phone due to their developing nervous system. #AACR. -- J Nat'l Cancer Inst‏ @JNCI_Now 3:21 PM - 2 Apr 12 via Twitter for iPhone • Tweet
  • @JNCI_Now Is this now the cell phone and cancer data established? I thought it was still controversial. #AACR. -- Naoto T. Ueno 上野直人‏ @teamoncology 3:42 PM - 2 Apr 12 via Twitterrific for Mac • Tweet

Last Word!


"Motherhood, apple pie & prevention... It was all presumed to be good." Dave Ransohoff #AACR"We did not ask if there were harms" #cancer. -- NCI Prevention‏ @NCIprevention 12:15 PM - 2 Apr 12 via Twitter for BlackBerry® • Tweet

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