Saturday, January 7, 2012

Most Common Somatic Mutations in Cancer

Here is a list of most common mutations in cancer genes.  This list is from a recent PLoS ONE article and it contains 60 most common mutations in 15 cancer genes.

A much longer list with 4000 genes is at COSMIC (Catalogue of Somatic Mutations in Cancer) database of Wellcome Trust Sanger institute. Dias-Santagata D, Lam Q, Vernovsky K, Vena N, Lennerz JK, Borger DR, Batchelor TT, Ligon KL, Iafrate AJ, Ligon AH, Louis DN, & Santagata S (2011). BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PloS one, 6 (3) PMID: 21479234

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